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According to previous paper, the hardness of semi-solid as ointments and suppositories causes the tough or skin, the pain and connected with absorption, the state of spread or the efficiency of drug. When the hardening agent or the softening agent is added to ointment whid, is registered on the pharmacopeia of the republic of Korea, the experimertal data by apparent logarithmic hardness are shown is Table 1. The results are as the folloring. 1) In case of the softening agent which is added to ointment base, each has shown two different equation with differnented slope as $K_1$ 수식 이미지 and $K_2$ 수식 이미지 value determined (Fig. 1,2). 2) When the hardening agent is added to same ointment base, these studies indicated that there is a direct correlation between $K_1$ 수식 이미지 and $K_2$ 수식 이미지. However, in case of softening agent $K_1$ 수식 이미지 and $K_1$ 수식 이미지 are not correlated as indicated in Fig. $3{\sim}8$ 수식 이미지. 3) On condition of same ointment base, the critical poit is proportional to $K_1$ 수식 이미지 4) The second effect is at least $3{\sim}17$ 수식 이미지 times more. sensitive than the first effect or in average 8.3 times more sensitive, Therefore, the results presented in this paper. Suggest that, when the drug is added to a certain ointment base, it should be added within this first effect before the critical point is reached.
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